Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASEH1 | O60930 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 10/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.40 |
| ▸ | CDK2 | P24941 | 10/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.40 |
| ▸ | CDK1 | P06493 | 5/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.40 |
| ▸ | TYMP | P19971 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 6/20 | 0.40 |
| ▸ | CCND1 | P24385 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5767035 | 0.83 | DAO (0.49) | MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL4777055 | 0.82 | MEN1 (0.44) | MEN1KMT2ACCNE2CCNE1CDK2 | |
| SCHEMBL4776840 | 0.80 | KMT2A (0.44) | MEN1KMT2AKDM4EALDH1A1PKM | |
| SCHEMBL4772366 | 0.79 | MEN1 (0.43) | MEN1KMT2AKDM4EALDH1A1PKM | |
| SCHEMBL4772481 | 0.79 | MEN1 (0.43) | MEN1KMT2ACCNE2CCNE1CDK2 | |
| SCHEMBL4774517 | 0.78 | MEN1 (0.42) | MEN1KMT2ACCNE2CCNE1CDK2 | |
| SCHEMBL4775804 | 0.78 | MEN1 (0.46) | MEN1KMT2AKDM4EALDH1A1PKM | |
| SCHEMBL4767403 | 0.77 | MEN1 (0.44) | MEN1KMT2ACCNE2CCNE1CDK2 | |
| SCHEMBL5769122 | 0.77 | MEN1 (0.56) | MEN1KMT2AKDM4EALDH1A1PKM | |
| SCHEMBL4767193 | 0.76 | TUBB4A (0.43) | MEN1KMT2ACCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881988-A1 | 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LTD. (GB) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006122200-A1 | 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LIMITED (GB) | 2006-11-16 | — | — | WO | disclosed |