Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PSD | A5PKW4 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | UCK2 | Q9BZX2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 2/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4767017 | 0.92 | POLB (0.40) | KMT2AHPGDALDH1A1KDM4EMAPT | |
| SCHEMBL4770146 | 0.90 | PIM1 (0.39) | MEN1KMT2AHPGDALDH1A1PSD | |
| SCHEMBL4776840 | 0.89 | KMT2A (0.44) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL4776202 | 0.89 | ALDH1A1 (0.39) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL4774517 | 0.88 | MEN1 (0.42) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL4775960 | 0.86 | AVPR2 (0.36) | MEN1KMT2AHPGDALDH1A1POLB | |
| SCHEMBL4772481 | 0.84 | MEN1 (0.43) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL4772366 | 0.84 | MEN1 (0.43) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL4776947 | 0.82 | RNASEH1 (0.49) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL4776863 | 0.81 | PIM1 (0.34) | MEN1KMT2ACCNB2CCNE2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881988-A1 | 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LTD. (GB) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006122200-A1 | 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LIMITED (GB) | 2006-11-16 | — | — | WO | disclosed |