Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 7/20 | 0.42 |
| ▸ | CDK2 | P24941 | 7/20 | 0.42 |
| ▸ | CDK9 | P50750 | 6/20 | 0.42 |
| ▸ | STK4 | Q13043 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 6/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.40 |
| ▸ | CDK7 | P50613 | 3/20 | 0.40 |
| ▸ | CCNH | P51946 | 2/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.40 |
| ▸ | IKBKB | O14920 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1634122 | 0.88 | GPR119 (0.46) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1633008 | 0.84 | CDK1 (0.46) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL4667180 | 0.78 | IKBKB (0.37) | JAK2JAK1TYK2JAK3IKBKB | |
| SCHEMBL1634712 | 0.77 | JAK2 (0.72) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1632574 | 0.73 | CA1 (0.47) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1632243 | 0.73 | IKBKB (0.47) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1633095 | 0.73 | CA2 (0.53) | SYKCDK1CDK2CDK9CA2 | |
| SCHEMBL1633530 | 0.72 | JAK2 (0.58) | JAK2JAK1TYK2JAK3CDK1 | |
| SCHEMBL1633546 | 0.72 | CDK1 (0.44) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1634265 | 0.72 | IKBKB (0.45) | SYKJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004615-A2 | QUINAZOLINES FOR PDK1 INHIBITION | Novartis AG (CH) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007117607-A2 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS AG (CH) | 2007-10-18 | — | — | WO | disclosed |