Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ASAH1 | Q13510 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2358520 | 0.85 | ELANE (0.42) | XIAP | |
| SCHEMBL3852283 | 0.85 | ELANE (0.42) | XIAP | |
| SCHEMBL2209223 | 0.83 | TP53 (0.39) | HDAC6BIRC2MMP2MAPTLMNA | |
| SCHEMBL2209218 | 0.83 | TP53 (0.39) | HDAC6BIRC2MMP2MAPTLMNA | |
| SCHEMBL4774566 | 0.79 | CES2 (0.46) | MAPTKMT2ALMNANPC1RAB9A | |
| SCHEMBL2212581 | 0.79 | ELANE (0.49) | — | |
| SCHEMBL2212579 | 0.79 | ELANE (0.49) | — | |
| SCHEMBL3832813 | 0.79 | CA12 (0.38) | CA12CA1CA2CA4HDAC6 | |
| SCHEMBL2358516 | 0.78 | TACR1 (0.36) | HDAC6BIRC2XIAPKMT2AASAH1 | |
| SCHEMBL2358522 | 0.78 | TACR1 (0.36) | HDAC6BIRC2XIAPKMT2AASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902065-A2 | CYCLIC AMIDE DERIVATIVES INHIBITORS OF THE INHIBITOR OF APOPTOSIS PROTEINS, THEIR PREPARATION, AND THEIR USE | Novartis AG (CH) | 2008-03-26 | — | — | EP | claimed |
| WO-2006133147-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2006-12-14 | — | — | WO | claimed |