Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 11/20 | 0.63 |
| ▸ | CCR3 | P51677 | 4/20 | 0.60 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4579190 | 0.80 | CCR3 (0.62) | GRIN2BCCR3GRIN1 | |
| SCHEMBL4579161 | 0.79 | CCR3 (0.71) | GRIN2BCCR3 | |
| SCHEMBL4786744 | 0.79 | CCR3 (0.67) | GRIN2BCCR3TMEM97 | |
| Hydrochloric Acid SCHEMBL7195898 | 0.78 | CCR3 (0.66) | GRIN2BCCR3TMEM97 | |
| Hydrochloric Acid SCHEMBL5756731 | 0.78 | CCR3 (0.66) | GRIN2BCCR3TMEM97 | |
| Hydrochloric Acid SCHEMBL7459822 | 0.78 | TMEM97 (0.60) | CCR3TMEM97 | |
| SCHEMBL4775599 | 0.78 | TMEM97 (0.60) | CCR3TMEM97 | |
| SCHEMBL253470 | 0.77 | DRD2 (0.51) | — | |
| Hydrochloric Acid SCHEMBL6056639 | 0.77 | TMEM97 (0.59) | CCR3TMEM97 | |
| Hydrochloric Acid SCHEMBL7187539 | 0.77 | TMEM97 (0.59) | CCR3TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348324-B2 | Cyclic amine compounds as CCR5 antagonists | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-03-25 | — | — | US | disclosed |
| EP-1886994-A1 | Cyclic amine compounds as CCR5 antagonists | Takeda Pharmaceutical Company Limited (JP) | 2008-02-13 | — | — | EP | disclosed |
| US-20030114443-A1 | Cyclic amine compounds as CCR5 antagonists | TOBIRA THERAPEUTICS, INC. | 2003-06-19 | — | — | US | disclosed |
| US-6562978-B1 | N-(3-(4-(4-(Aminocarbonyl)benzyl)-1-piperidinyl)propyl)-N-(3, 4-dichlorophenyl)-1-(methylsulfonyl)-4-piperidinecarboxamide or a salt thereof for treatment of AIDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-05-13 | — | — | US | disclosed |
| EP-1220842-A1 | CYCLIC AMINE COMPOUNDS AS CCR5 ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 2002-07-10 | — | — | EP | disclosed |
| WO-2001025200-A1 | CYCLIC AMINE COMPOUNDS AS CCR5 ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114443-A1 | Cyclic amine compounds as CCR5 antagonists | CCR5, CCR1, CCR3 | GRIN2B 226/4885CCR3 3/4885GRIN1 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.