Bisdisulizole

Bisdisulizole

SCHEMBL4777834

O=S(=O)(O)c1cc(S(=O)(=O)O)c2nc(-c3ccc(-c4nc5c(S(=O)(=O)O)cc(S(=O)(=O)O)cc5[nH]4)cc3)[nH]c2c1.[NaH].[NaH]

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 1/20 0.51
SCD O00767 5/20 0.42
DHODH Q02127 6/20 0.40
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
PARP1 P09874 1/20 0.39
NPBWR1 P48145 1/20 0.39
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
MITF O75030 1/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 1/20 0.38
HPGD P15428 1/20 0.38
BLM P54132 1/20 0.38
GFER P55789 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bisdisulizole SCHEMBL1830829 1.00 HDAC6 (0.51) HDAC6SCDDHODHCYP3A4CYP2D6
Bisdisulizole SCHEMBL62139 0.98 HDAC6 (0.52) HDAC6SCDDHODHCYP3A4CYP2D6
Bisdisulizole SCHEMBL29507075 0.98 HDAC6 (0.52) HDAC6SCDDHODHCYP3A4CYP2D6
Bisdisulizole SCHEMBL29507102 0.98 HDAC6 (0.52) HDAC6SCDDHODHCYP3A4CYP2D6
SCHEMBL6575742 0.92 HDAC6 (0.63) HDAC6SCDDHODHCYP3A4CYP2D6
SCHEMBL14224890 0.91 HDAC6 (0.46) HDAC6SCDDHODHCYP3A4CYP2D6
SCHEMBL22902385 0.91 HDAC6 (0.46) HDAC6SCDDHODHCYP3A4CYP2D6
SCHEMBL20848229 0.91 HDAC6 (0.46) HDAC6SCDDHODHKDM4EALDH1A1
Bisdisulizole SCHEMBL1830834 0.91 HDAC6 (0.49) HDAC6SCDDHODHCYP3A4CYP2D6
Bisdisulizole SCHEMBL29366474 0.91 HDAC6 (0.49) HDAC6SCDDHODHCYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1990372-A2 Water soluble UV filters Ciba Holding Inc. (CH) 2008-11-12 EP disclosed
US-6368578-B1 MIXTURE BEIERSDORF AG (DE) 2002-04-09 US disclosed
US-6355230-B2 FOR ULTRAVIOLET-A RADIATION PROTECTION; SOLUBILITY BEIERSDORF AG (DE) 2002-03-12 US disclosed
US-20010026790-A1 Cosmetic and dermatological light protection formulations wirh a content of benzotriazole derivatives and alkyl naphthalates BEIERSDORF AG (DE) 2001-10-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010026790-A1 Cosmetic and dermatological light protection formulations wirh a content of benzotriazole derivatives and alkyl naphthalates WHR1, WIZ, LBR HDAC6 1445/4885SCD 4138/4885DHODH 863/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.