Bisdisulizole

Bisdisulizole

SCHEMBL62139

O=S(=O)(O)c1cc(S(=O)(=O)O)c2nc(-c3ccc(-c4nc5c(S(=O)(=O)O)cc(S(=O)(=O)O)cc5[nH]4)cc3)[nH]c2c1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 1/20 0.52
SCD O00767 5/20 0.43
DHODH Q02127 6/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
PARP1 P09874 1/20 0.40
NPBWR1 P48145 1/20 0.40
KDM4E B2RXH2 1/20 0.39
MEN1 O00255 1/20 0.39
MITF O75030 1/20 0.39
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39
HPGD P15428 1/20 0.39
BLM P54132 1/20 0.39
GFER P55789 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bisdisulizole SCHEMBL29507102 1.00 HDAC6 (0.52) HDAC6SCDDHODHCYP3A4CYP2D6
Bisdisulizole SCHEMBL29507075 1.00 HDAC6 (0.52) HDAC6SCDDHODHCYP3A4CYP2D6
Bisdisulizole SCHEMBL4777834 0.98 HDAC6 (0.51) HDAC6SCDDHODHCYP3A4CYP2D6
Bisdisulizole SCHEMBL1830829 0.98 HDAC6 (0.51) HDAC6SCDDHODHCYP3A4CYP2D6
SCHEMBL6575742 0.93 HDAC6 (0.63) HDAC6SCDDHODHCYP3A4CYP2D6
SCHEMBL14224890 0.92 HDAC6 (0.46) HDAC6SCDDHODHCYP3A4CYP2D6
SCHEMBL22902385 0.92 HDAC6 (0.46) HDAC6SCDDHODHCYP3A4CYP2D6
SCHEMBL20848229 0.92 HDAC6 (0.46) HDAC6SCDDHODHKDM4EALDH1A1
Bisdisulizole SCHEMBL29366474 0.92 HDAC6 (0.49) HDAC6SCDDHODHCYP3A4CYP2D6
Bisdisulizole SCHEMBL1830834 0.92 HDAC6 (0.49) HDAC6SCDDHODHCYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1157 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3578558-B1 HIGHLY EFFECTIVE PHOTOPROTECTIVE AGENTS 3V SIGMA SPA (IT) 2021-02-24 EP claimed
EP-3238694-B1 SUNSCREEN PRODUCT COMPRISING HYDROXYAPATITE AS PHYSICAL FILTER KALICHEM S R L (IT) 2020-10-28 EP claimed
US-20190099342-A1 COOLING PRODUCT SYMRISE AG (DE) 2019-04-04 US claimed
EP-3238694-A1 SUNSCREEN PRODUCT COMPRISING HYDROXYAPATITE AS PHYSICAL FILTER Kalichem S.r.l. (IT) 2017-11-01 EP claimed
EP-2410974-B1 SUNSCREEN COMPOSITION COMPRISING HYDROXYAPATITE AS PHYSICAL SOLAR FILTER KALICHEM ITALIA S R L (IT) 2017-05-24 EP claimed
US-20150174045-A1 LIGHT PROTECTING COMPOSITION WITH REDUCED TOTAL AMOUNT OF UV FILTER CONTAINING A POLYSILOXANE-BASED UV FILTER DSM IP ASSETS B.V. (NL) 2015-06-25 US claimed
US-8540972-B2 Sunscreen product comprising hydroxyapatite as physical filter KALICHEM ITALIA S.R.L. (IT) 2013-09-24 US claimed
US-20120014891-A1 SUNSCREEN PRODUCT COMPRISING HYDROXYAPATITE AS PHYSICAL FILTER KALICHEM ITALIA S.R.L. (IT) 2012-01-19 US claimed
US-20090104135-A1 Use of Mineral/Organic Composite Material in the Form of an Ultraviolet Radiation Protective Agent LVMH RECHERCHE (FR) 2009-04-23 US claimed
WO-2007110415-A2 USE OF DIACETYL TRIMERS AND COSMETIC OR THERAPEUTIC FORMULATIONS CONTAINING THESE COMPOUNDS SYMRISE GMBH & CO. KG (DE) 2007-10-04 WO claimed
WO-2005032504-A1 COSMETIC PREPARATION CONTAINING HIGH MOLECULAR ANTIOXIDANT COMPONENT CPN SPOL. S.R.O. (CZ) 2005-04-14 WO claimed
WO-2003030856-A1 SILOXANE SUNSCREEN COMPOSITIONS ROCHE VITAMINS AG (CH) 2003-04-17 WO claimed
US-6468509-B2 Sunscreen composition containing sol-gel microcapsules SOL-GEL TECHNOLOGIES LTD. (IL) 2002-10-22 US claimed
US-20020131939-A1 Hair protection compositions ROCHE VITAMINS INC. 2002-09-19 US claimed
US-20020037261-A1 Sunscreen composition containing sol-gel microcapsules LAPIDOT NAO (IL) 2002-03-28 US claimed
EP-4279532-B1 CROSSLINKED POLYGLYCEROL PARTIAL ESTERS EVONIK OPERATIONS GMBH (DE) 2026-03-25 EP disclosed
EP-4279531-B1 CROSSLINKED POLYGLYCEROL ESTERS EVONIK OPERATIONS GMBH (DE) 2026-02-25 EP disclosed
EP-1059082-A1 Use of substituted vinyltetrahydronaphthalenes and vinylbenzotetrahydropyrans as sunscreens BASF AKTIENGESELLSCHAFT (DE) 2000-12-13 EP disclosed
EP-1046391-A2 Use of aminosubstituted hydroxybenzophenones as photostable UV-filters in cosmetic and pharmaceutical preparations BASF AKTIENGESELLSCHAFT (DE) 2000-10-25 EP disclosed
EP-1008593-A1 Benzylidene-gamma-butyrolactones, process for their production and use thereof as UV absorbers HAARMANN & REIMER GMBH (DE) 2000-06-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190099342-A1 COOLING PRODUCT TRPA1, TRPV2, NISCH HDAC6 2080/4885SCD 728/4885DHODH 755/4885
US-20150174045-A1 LIGHT PROTECTING COMPOSITION WITH REDUCED TOTAL AMOUNT OF UV FILTER CONTAINING A POLYSILOXANE-BASED UV FILTER ERCC4, ERCC2, ERCC1 HDAC6 1220/4885SCD 4390/4885DHODH 1860/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.