Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 19/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | HTR1E | P28566 | 1/20 | 0.50 |
| ▸ | HTR1F | P30939 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945974 | 0.94 | HTR6 (0.54) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL4776877 | 0.93 | HTR6 (0.53) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL947301 | 0.92 | HTR6 (0.70) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL946693 | 0.91 | HTR6 (0.55) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL4772638 | 0.89 | HTR6 (0.54) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL4769961 | 0.88 | HTR6 (0.59) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL945925 | 0.85 | HTR6 (0.69) | HTR6CYP3A4CYP2D6PPARGPPARD | |
| SCHEMBL5225858 | 0.84 | HTR6 (0.77) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL4775130 | 0.84 | HTR6 (0.71) | HTR6CYP3A4CYP2D6PPARGPPARD | |
| SCHEMBL4774930 | 0.83 | HTR6 (0.52) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581492-B1 | N-ARYLSULFONYL-3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | SUVEN LIFE SCIENCES LTD (IN) | 2008-07-16 | — | — | EP | disclosed |