Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FOS | P01100 | 1/20 | 0.37 |
| ▸ | JUN | P05412 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3291033 | 0.92 | MEN1 (0.49) | MEN1KMT2AALDH1A1TDP1POLB | |
| SCHEMBL3531655 | 0.91 | MEN1 (0.50) | MEN1KMT2AALDH1A1TDP1POLB | |
| SCHEMBL12556585 | 0.81 | MEN1 (0.51) | MEN1KMT2AALDH1A1TDP1POLB | |
| SCHEMBL10991726 | 0.79 | ALDH1A1 (0.44) | MEN1KMT2AALDH1A1TDP1POLB | |
| SCHEMBL3525725 | 0.76 | MEN1 (0.46) | MEN1KMT2AALDH1A1TDP1POLB | |
| SCHEMBL12631824 | 0.76 | MEN1 (0.47) | MEN1KMT2AALDH1A1TDP1POLB | |
| SCHEMBL9955978 | 0.75 | MEN1 (0.51) | MEN1KMT2AALDH1A1TDP1POLB | |
| SCHEMBL10993583 | 0.74 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL10997335 | 0.72 | MAPT (0.46) | MEN1KMT2AALDH1A1POLBMAPT | |
| SCHEMBL5266863 | 0.72 | ALDH1A1 (0.61) | MEN1KMT2AALDH1A1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945637-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007033137-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |