Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | FOS | P01100 | 1/20 | 0.45 |
| ▸ | JUN | P05412 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11584325 | 0.83 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1SYKMAPT | |
| SCHEMBL16446231 | 0.83 | RAB9A (0.46) | MEN1KMT2AALDH1A1TDP1POLB | |
| SCHEMBL11020556 | 0.83 | ALDH1A1 (0.55) | MEN1KMT2AALDH1A1TDP1POLB | |
| SCHEMBL3531655 | 0.82 | MEN1 (0.50) | MEN1KMT2AALDH1A1TDP1POLB | |
| SCHEMBL11015988 | 0.82 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1TDP1POLB | |
| SCHEMBL4260559 | 0.82 | MEN1 (0.56) | MEN1KMT2AALDH1A1TDP1POLB | |
| SCHEMBL3532279 | 0.81 | ALDH1A1 (0.56) | MEN1KMT2AALDH1A1TDP1POLB | |
| SCHEMBL11021116 | 0.81 | HTT (0.48) | MEN1KMT2AALDH1A1TDP1POLB | |
| SCHEMBL3291033 | 0.81 | MEN1 (0.49) | MEN1KMT2AALDH1A1TDP1POLB | |
| SCHEMBL16446548 | 0.79 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015019037-A1 | PHARMACEUTICAL COMPOUNDS | ALMAC DISCOVERY LIMITED (GB) | 2015-02-12 | — | — | WO | disclosed |
| WO-2012085166-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085166-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |