Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 5/20 | 0.43 |
| ▸ | BRAF | P15056 | 4/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783075 | 0.91 | PLAU (0.42) | RAF1BRAFPLAUMAPK14MAPK13 | |
| SCHEMBL4778219 | 0.90 | NAPEPLD (0.40) | RAF1BRAFPLAUMAPK14MAPK13 | |
| SCHEMBL4781500 | 0.89 | PLAU (0.41) | RAF1BRAFPLAUMAPK14MAPK13 | |
| SCHEMBL4728307 | 0.89 | RAF1 (0.45) | RAF1BRAFPLAUMAPK14MAPK13 | |
| SCHEMBL4782767 | 0.88 | CNR2 (0.42) | RAF1BRAFPLAUMAPK14 | |
| SCHEMBL4781167 | 0.88 | MAPK14 (0.47) | RAF1BRAFPLAUMAPK14MAPK13 | |
| SCHEMBL4780448 | 0.87 | RAF1 (0.43) | RAF1BRAFPLAUMAPK14 | |
| SCHEMBL4781361 | 0.87 | ACKR3 (0.45) | RAF1BRAFPLAUMAPK14 | |
| SCHEMBL4936382 | 0.86 | HPGD (0.41) | BRAFMAPK14 | |
| SCHEMBL4783679 | 0.86 | MAPK14 (0.48) | RAF1BRAFPLAUMAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |