Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 3/20 | 0.48 |
| ▸ | MGLL | Q99685 | 12/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14311291 | 0.83 | HTR3A (0.58) | HTR3AMAPT | |
| SCHEMBL14258880 | 0.77 | TSHR (0.47) | HTR3AMAPT | |
| SCHEMBL20897573 | 0.77 | HTR3A (0.72) | HTR3APARP1MGLL | |
| Hydrochloric Acid SCHEMBL20897549 | 0.76 | HTR3A (0.70) | HTR3APARP1MGLL | |
| Hydrochloric Acid SCHEMBL20897547 | 0.76 | HTR3A (0.70) | HTR3APARP1MGLL | |
| Hydrochloric Acid SCHEMBL29784162 | 0.76 | HTR3A (0.70) | HTR3APARP1MGLL | |
| SCHEMBL4726050 | 0.75 | TSHR (0.46) | HTR3AMAPT | |
| SCHEMBL4725671 | 0.75 | TSHR (0.46) | HTR3AMAPT | |
| SCHEMBL15542775 | 0.74 | CYP1A2 (0.52) | MAPT | |
| Acetic Acid SCHEMBL20897485 | 0.74 | HTR3A (0.67) | HTR3AMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076924-A1 | Piperazines as P2X7 antagonists | ABBOTT LABORATORIES | 2008-03-27 | — | — | US | disclosed |
| WO-2008005368-A2 | PIPERAZINES AS P2X7 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076924-A1 | Piperazines as P2X7 antagonists | P2RX7, P2RX1, P2RX2 | HTR3A 180/4885PARP1 1412/4885MGLL 4241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.