Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 3/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MC5R | P33032 | 1/20 | 0.32 |
| ▸ | MC1R | Q01726 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019458 | 0.90 | DPP4 (0.35) | MC4RDPP4DPP8ALDH1A1MAPT | |
| SCHEMBL4018665 | 0.89 | DPP4 (0.37) | MC4RDPP4DPP8ALDH1A1MAPT | |
| SCHEMBL4020144 | 0.88 | DPP4 (0.38) | MC4RDPP4DPP8ALDH1A1MAPT | |
| SCHEMBL4028039 | 0.88 | DPP4 (0.36) | MC4RDPP4DPP8ALDH1A1MAPT | |
| SCHEMBL4022700 | 0.85 | DPP4 (0.34) | MC4RDPP4DPP8ALDH1A1MAPT | |
| SCHEMBL4025128 | 0.84 | HRH3 (0.33) | DPP4DPP8KDM4EPKMTSHR | |
| SCHEMBL4028057 | 0.84 | ALDH1A1 (0.37) | MC4RDPP4DPP8ALDH1A1MAPT | |
| SCHEMBL4028055 | 0.84 | ALDH1A1 (0.37) | MC4RDPP4DPP8ALDH1A1MAPT | |
| SCHEMBL4021833 | 0.83 | DPP4 (0.36) | DPP4DPP8ALDH1A1MAPTKDM4E | |
| SCHEMBL4749105 | 0.82 | MET (0.36) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |