Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.43 |
| ▸ | FPR2 | P25090 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4354381 | 0.74 | HRH4 (0.50) | HRH4HRH3HDAC2HDAC3HDAC1 | |
| SCHEMBL4359804 | 0.70 | HRH4 (0.68) | HRH4HRH3 | |
| SCHEMBL12467234 | 0.70 | CHEK1 (0.39) | HRH4FPR2SCN9AHRH3HDAC2 | |
| SCHEMBL1693574 | 0.70 | FPR2 (0.39) | HRH4FPR2SCN9AHRH3KCNH2 | |
| SCHEMBL7512808 | 0.70 | PTPN11 (0.38) | HRH4FPR2SCN9AHDAC3 | |
| SCHEMBL4356738 | 0.70 | HRH4 (0.51) | HRH4HRH3ROCK2 | |
| SCHEMBL4101186 | 0.70 | PDE4A (0.49) | HRH4FPR2SCN9A | |
| SCHEMBL652228 | 0.69 | HRH4 (0.33) | HRH4 | |
| SCHEMBL795138 | 0.69 | FPR2 (0.36) | HRH4FPR2SCN9AHRH3KCNH2 | |
| SCHEMBL4363831 | 0.68 | PRKDC (0.52) | HRH4HRH3TSHRCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009078-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |