Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.37 |
| ▸ | HTR2C | P28335 | 6/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778898 | 0.83 | ALDH1A1 (0.37) | HTR2AHTR2CRAB9AKDM4EALDH1A1 | |
| SCHEMBL14259766 | 0.72 | HTR2A (0.51) | HTR2AHTR2C | |
| SCHEMBL4779455 | 0.71 | HTR2A (0.37) | HTR2AHTR2C | |
| SCHEMBL4881352 | 0.71 | HTR2A (0.39) | HTR2AHTR2CMEN1KMT2A | |
| SCHEMBL1165844 | 0.70 | HTR2A (0.63) | HTR2AHTR2CKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL1166100 | 0.69 | HTR2A (0.62) | HTR2AHTR2CKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL1165825 | 0.69 | HTR2A (0.62) | HTR2AHTR2CKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL5245872 | 0.66 | HTR2A (0.54) | HTR2AHTR2C | |
| SCHEMBL1065555 | 0.65 | HRH3 (0.41) | DRD2MAOARAB9AMEN1POLB | |
| SCHEMBL1166025 | 0.65 | HTR2A (0.60) | HTR2AHTR2CALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008027483-A1 | BENZOFURAN DERIVATIVES AS MODULATORS OF THE 5-HT2A RECEPTOR | ARENA PHARMACEUTICALS, INC. (US) | 2008-03-06 | — | — | WO | disclosed |