Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 19/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780633 | 0.80 | AURKA (0.49) | IGF1RAURKAAURKBALK | |
| SCHEMBL4778719 | 0.77 | VCP (0.46) | IGF1RAURKAAURKBALKCYP3A4 | |
| SCHEMBL4780844 | 0.76 | KDM4E (0.47) | IGF1RAURKAAURKBALK | |
| SCHEMBL4793118 | 0.76 | KDM4E (0.51) | IGF1RAURKAAURKBALKCYP3A4 | |
| SCHEMBL4792622 | 0.75 | KDM4E (0.49) | — | |
| SCHEMBL4782903 | 0.74 | VCP (0.49) | IGF1RAURKAAURKBALK | |
| SCHEMBL4782147 | 0.73 | IGF1R (0.49) | IGF1RAURKACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4795408 | 0.71 | AURKA (0.49) | IGF1RAURKAAURKBALK | |
| SCHEMBL4796341 | 0.69 | AURKA (0.45) | IGF1RAURKAAURKBALK | |
| SCHEMBL4780825 | 0.69 | AURKA (0.45) | IGF1RAURKAAURKBALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | claimed |
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | disclosed |