Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ACP1 | P24666 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | APAF1 | O14727 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782567 | 0.91 | IGF1R (0.48) | IGF1RKDM4ENPC1RAB9AMAPT | |
| SCHEMBL4781252 | 0.86 | KDM4E (0.52) | IGF1RKDM4ENPC1RAB9AACP1 | |
| SCHEMBL4794943 | 0.83 | KDM4E (0.48) | KDM4ENPC1RAB9AMAPTAPAF1 | |
| SCHEMBL4796798 | 0.80 | EGFR (0.47) | KDM4ENPC1RAB9AMAPTAPAF1 | |
| SCHEMBL4782089 | 0.80 | KDM4E (0.51) | KDM4ENPC1RAB9AMAPTAPAF1 | |
| SCHEMBL4780159 | 0.79 | KDM4E (0.45) | KDM4ENPC1RAB9AMAPTAPAF1 | |
| SCHEMBL4782136 | 0.75 | MAPT (0.45) | IGF1RKDM4ENPC1RAB9AMAPT | |
| SCHEMBL4782085 | 0.74 | BCAT1 (0.49) | KDM4ENPC1RAB9AMAPTALOX12 | |
| SCHEMBL4796043 | 0.73 | ALDH1A1 (0.51) | IGF1RKDM4ENPC1RAB9AMAPT | |
| SCHEMBL4778541 | 0.73 | IGF1R (0.55) | IGF1RCYP3A4CYP2D6CYP2C19AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | claimed |
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | disclosed |