Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725061 | 0.90 | ATM (0.57) | PDK1PDE10AATMPDGFRBPDGFRA | |
| SCHEMBL31469355 | 0.86 | ATM (0.45) | PDK1PDE10AATMPDGFRBPDGFRA | |
| SCHEMBL4727998 | 0.85 | EGFR (0.58) | ATMEGFRKIT | |
| SCHEMBL4725216 | 0.80 | EGFR (0.58) | PDGFRBPDGFRAEGFRKIT | |
| SCHEMBL4729758 | 0.79 | EGFR (0.48) | PDK1ATMPDGFRBPDGFRAEGFR | |
| SCHEMBL4783706 | 0.77 | EGFR (0.52) | EGFRKITFYN | |
| SCHEMBL4728978 | 0.75 | PDE10A (0.49) | PDK1PDE10AATMPDGFRBPDGFRA | |
| SCHEMBL4725516 | 0.75 | PDE10A (0.49) | PDK1PDE10AATMPDGFRBPDGFRA | |
| SCHEMBL4782102 | 0.74 | WHR1 (0.61) | ATMPDGFRBPDGFRAEGFRKIT | |
| SCHEMBL23726135 | 0.74 | KIT (0.57) | PDGFRBPDGFRAEGFRENPP1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |