Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 4/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.45 |
| ▸ | RORB | Q92753 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | KIF5B | P33176 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727998 | 0.82 | EGFR (0.58) | EGFRBRAFCSF1RKITRET | |
| SCHEMBL4729925 | 0.78 | KMO (0.44) | EGFRABCG2BRAFKDRMAPK14 | |
| SCHEMBL4725216 | 0.77 | EGFR (0.58) | EGFRBRAFCSF1RKITRET | |
| SCHEMBL4778871 | 0.77 | PDK1 (0.49) | EGFRKITFYN | |
| SCHEMBL4727531 | 0.75 | EGFR (0.46) | EGFRABCG2BRAFCSF1RKIT | |
| SCHEMBL6181412 | 0.72 | EGFR (0.63) | EGFRCSF1RKITRETKDR | |
| SCHEMBL26100901 | 0.72 | KDR (0.44) | EGFRBRAFKITKDR | |
| SCHEMBL7801693 | 0.71 | ADORA2A (0.50) | EGFRABCG2CSF1RRORB | |
| SCHEMBL26110627 | 0.71 | EGFR (0.47) | EGFRKITKDR | |
| SCHEMBL4782102 | 0.71 | WHR1 (0.61) | EGFRCSF1RKITRETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |