Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sphingosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 6/20 | 0.85 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.85 |
| ▸ | MEN1 | O00255 | 5/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.85 |
| ▸ | MAPT | P10636 | 4/20 | 0.85 |
| ▸ | CETP | P11597 | 4/20 | 0.85 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.85 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.85 |
| ▸ | THRB | P10828 | 3/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.85 |
| ▸ | GMNN | O75496 | 2/20 | 0.85 |
| ▸ | LMNA | P02545 | 2/20 | 0.85 |
| ▸ | GLA | P06280 | 2/20 | 0.85 |
| ▸ | POLB | P06746 | 2/20 | 0.85 |
| ▸ | CXCR5 | P32302 | 2/20 | 0.85 |
| ▸ | CCR6 | P51684 | 2/20 | 0.85 |
| ▸ | BLM | P54132 | 2/20 | 0.85 |
| ▸ | UBE2N | P61088 | 2/20 | 0.85 |
| ▸ | TP53 | P04637 | 2/20 | 0.85 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sphingosine SCHEMBL19137 | 1.00 | SPHK2 (0.85) | SPHK2SPHK1MEN1KMT2AMAPT | |
| Sphingosine SCHEMBL21439824 | 1.00 | SPHK2 (0.85) | SPHK2SPHK1MEN1KMT2AMAPT | |
| Sphingosine SCHEMBL31018980 | 1.00 | SPHK2 (0.85) | SPHK2SPHK1MEN1KMT2AMAPT | |
| Sphingosine SCHEMBL16188315 | 1.00 | SPHK2 (0.85) | SPHK2SPHK1MEN1KMT2AMAPT | |
| Sphingosine SCHEMBL320150 | 1.00 | SPHK2 (0.85) | SPHK2SPHK1MEN1KMT2AMAPT | |
| SCHEMBL22986939 | 0.92 | SPHK2 (1.00) | SPHK2SPHK1MEN1KMT2AMAPT | |
| Sphingosine SCHEMBL21114357 | 0.92 | SPHK2 (1.00) | SPHK2SPHK1MEN1KMT2AMAPT | |
| Sphingosine SCHEMBL470867 | 0.92 | SPHK2 (1.00) | SPHK2SPHK1MEN1KMT2AMAPT | |
| SCHEMBL21428474 | 0.92 | SPHK2 (1.00) | SPHK2SPHK1MEN1KMT2AMAPT | |
| SCHEMBL21428477 | 0.92 | SPHK2 (1.00) | SPHK2SPHK1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006007-A2 | DEFECTIVE CYSTIC FIBROSIS TRANSDUCTION REGULATOR (CFTR) CAUSES INCREASED SPHINGOLIPID SYNTHESIS | COLUMBIA UNIVERSITY (US) | 2008-01-10 | — | — | WO | disclosed |