Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 4/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779406 | 0.91 | RXFP1 (0.42) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL4728307 | 0.85 | RAF1 (0.45) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4778221 | 0.85 | RAF1 (0.43) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4781167 | 0.84 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4783406 | 0.83 | RXFP1 (0.40) | MAPK14MAPTNAMPTRXFP1DHODH | |
| SCHEMBL4780448 | 0.83 | RAF1 (0.43) | MAPK14RAF1BRAF | |
| SCHEMBL4727303 | 0.83 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL4783679 | 0.82 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4783075 | 0.82 | PLAU (0.42) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4781500 | 0.81 | PLAU (0.41) | MAPK14MAPK13MAPK12MAPK11RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |