Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 3/20 | 0.34 |
| ▸ | MAOA | P21397 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL172454 | 0.75 | CHRNB2 (0.59) | PRCPSLC18A3SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL1413442 | 0.75 | CHRNB2 (0.59) | PRCPSLC18A3SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL30298452 | 0.75 | CHRNB2 (0.59) | PRCPSLC18A3SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL8124800 | 0.72 | PRCP (0.42) | PRCPSLC18A3SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL28615303 | 0.72 | PRCP (0.42) | PRCPSLC18A3SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL167264 | 0.70 | CHRNB2 (0.63) | CHRNB2CHRNA4MEN1KMT2ACHRNA7 | |
| SCHEMBL170704 | 0.70 | CHRNB2 (0.63) | CHRNB2CHRNA4MEN1KMT2ACHRNA7 | |
| SCHEMBL21232 | 0.70 | CHRNB2 (0.63) | CHRNB2CHRNA4MEN1KMT2ACHRNA7 | |
| SCHEMBL4165235 | 0.70 | SLC18A3 (0.40) | PRCPSLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL1688451 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008001134-A1 | 1,2,3,8,9,9A-HEXAHYDRO-7H-BENZO(DE)-1,7-NAPHTHYRIDIN-7-ONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2008-01-03 | — | — | WO | disclosed |