Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | LDHA | P00338 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.61 |
| ▸ | USP2 | O75604 | 4/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | NCF1 | P14598 | 1/20 | 0.60 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.60 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5534962 | 0.82 | CYP1A2 (0.62) | APPCYP1A2CYP3A4HSD17B10KDM4E | |
| SCHEMBL8897898 | 0.82 | CYP1A2 (0.68) | APPCYP1A2CYP3A4HSD17B10KDM4E | |
| SCHEMBL4358305 | 0.82 | TLR7 (0.54) | APPCYP1A2CYP3A4HSD17B10KDM4E | |
| SCHEMBL10838568 | 0.81 | APP (0.74) | APP | |
| SCHEMBL1084153 | 0.81 | CYP1A2 (0.79) | CYP1A2CYP3A4HSD17B10KDM4ECYP2C19 | |
| SCHEMBL23513886 | 0.81 | TLR7 (0.47) | APPCYP1A2CYP3A4HSD17B10KDM4E | |
| SCHEMBL29653748 | 0.81 | TLR7 (0.47) | APPCYP1A2CYP3A4HSD17B10KDM4E | |
| SCHEMBL13975549 | 0.81 | APP (0.83) | APPCYP1A2CYP2D6TLR8TLR7 | |
| SCHEMBL28414968 | 0.80 | LDHA (0.62) | APPCYP1A2CYP3A4HSD17B10KDM4E | |
| SCHEMBL4867969 | 0.78 | MAPT (0.59) | CYP1A2CYP3A4HSD17B10KDM4ELDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009078-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |