Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25466055 | 0.85 | KDM4E (0.50) | IDO1BRD4SMN1; SMN2MAPT | |
| SCHEMBL12411094 | 0.82 | L3MBTL1 (0.54) | LRRK2IDO1BRD4POLBHTT | |
| SCHEMBL31354326 | 0.82 | MDM4 (0.51) | IRAK4BRD4SMN1; SMN2HTT | |
| SCHEMBL15650965 | 0.81 | MAP2K3 (0.50) | IRAK4BRD4SMN1; SMN2POLBMAPT | |
| SCHEMBL19691222 | 0.79 | MEN1 (0.57) | IRAK4BRD4POLB | |
| SCHEMBL15357784 | 0.77 | BRD4 (0.68) | BRD4ADORA2BSMN1; SMN2MAPTHTT | |
| SCHEMBL28051960 | 0.77 | MKNK1 (0.50) | LRRK2IRAK4IDO1BRD4SMN1; SMN2 | |
| SCHEMBL25466053 | 0.75 | KDM4E (0.47) | IDO1BRD4SMN1; SMN2MAPT | |
| SCHEMBL25466061 | 0.75 | KDM4E (0.47) | IDO1BRD4SMN1; SMN2MAPT | |
| SCHEMBL27932430 | 0.75 | GLO1 (0.54) | IRAK4BRD4SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008431-A2 | HETEROARYL SULFONAMIDES AND CCR2/CCR9 | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |