Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 6/20 | 0.65 |
| ▸ | PDE4A | P27815 | 5/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.65 |
| ▸ | TNF | P01375 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.65 |
| ▸ | ACHE | P22303 | 2/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.65 |
| ▸ | BLM | P54132 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23144749 | 0.96 | PDE4A (0.70) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27348729 | 0.96 | PDE4A (0.70) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27334771 | 0.96 | PDE4A (0.70) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| Pentifylline SCHEMBL147256 | 0.96 | PDE4A (0.70) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL266179 | 0.95 | PDE4A (0.72) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8682905 | 0.92 | ADORA2B (0.62) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8378764 | 0.92 | ADORA2B (0.62) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8149700 | 0.92 | ADORA2B (0.62) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8144893 | 0.92 | ADORA2B (0.62) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL516018 | 0.90 | PDE4A (0.78) | ADORA2BPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008011518-A2 | ENCAPSULATION SYSTEM | DIAKINE THERAPEUTICS, INC. (US) | 2008-01-24 | — | — | WO | disclosed |
| EP-1171442-B1 | XANTHINE DERIVATIVES AND ANALOGS AS CELL SIGNALLING INHIBITORS | CELL THERAPEUTICS INC (US) | 2005-12-07 | — | — | EP | disclosed |
| US-6878715-B1 | Therapeutic compounds for inhibiting interleukin-12 signals and method for using same | CELL THERAPEUTICS, INC. (US) | 2005-04-12 | — | — | US | disclosed |
| US-20050049262-A1 | Therapeutic compounds for inhibiting interleukin-12 signaling and methods for using same | CELL THERAPEUTICS, INC. (US) | 2005-03-03 | — | — | US | disclosed |
| EP-1171442-A1 | XANTHINE DERIVATIVES AND ANALOGS AS CELL SIGNALLING INHIBITORS | CELL THERAPEUTICS, INC. (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000061583-A1 | XANTHINE DERIVATIVES AND ANALOGS AS CELL SIGNALING INHIBITORS | CELL THERAPEUTICS, INC. (US) | 2000-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049262-A1 | Therapeutic compounds for inhibiting interleukin-12 signaling and methods for using same | IL2, CCR10, CCR1 | ADORA2B 3204/4885PDE4A 4128/4885PDE4B 4566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.