Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | RAF1 | P04049 | 18/20 | 0.49 |
| ▸ | BRAF | P15056 | 18/20 | 0.49 |
| ▸ | SMO | Q99835 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14292736 | 0.91 | RAF1 (0.50) | RAF1BRAF | |
| SCHEMBL4779868 | 0.84 | RAF1 (0.49) | MAPK14RAF1BRAF | |
| SCHEMBL4880516 | 0.81 | RAF1 (0.52) | MAPK14RAF1BRAF | |
| SCHEMBL14293640 | 0.80 | RAF1 (0.51) | MAPK14RAF1BRAF | |
| SCHEMBL4408184 | 0.79 | MAPK14 (0.56) | MAPK14RAF1BRAFSMO | |
| SCHEMBL4551884 | 0.78 | MAPK14 (0.64) | MAPK14RAF1BRAFSMO | |
| SCHEMBL4726694 | 0.77 | RAF1 (0.41) | MAPK14RAF1BRAFSMO | |
| SCHEMBL4551753 | 0.77 | MAPK14 (0.64) | MAPK14RAF1BRAFSMO | |
| SCHEMBL4725060 | 0.77 | ALDH1A1 (0.46) | MAPK14RAF1BRAF | |
| SCHEMBL4727582 | 0.77 | RAF1 (0.41) | MAPK14RAF1BRAFSMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |