Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3493726 | 0.80 | TSHR (0.58) | MAPTGAARAB9ASMN1; SMN2KMT2A | |
| SCHEMBL9979815 | 0.79 | AR (0.64) | ARMAPTGAARAB9APRKCZ | |
| SCHEMBL276323 | 0.78 | AR (0.56) | ARMAPTGAARAB9APRKCZ | |
| SCHEMBL30741033 | 0.77 | GCGR (0.56) | ARMAPTSMN1; SMN2ADORA3KMT2A | |
| SCHEMBL28362521 | 0.77 | KCNJ1 (0.64) | ARMAPTGAARAB9APRKCZ | |
| SCHEMBL7640668 | 0.77 | MAPT (0.57) | ARMAPTGAARAB9APRKCZ | |
| SCHEMBL30740871 | 0.76 | ALDH1A1 (0.49) | MAPTGAARAB9ASMN1; SMN2ADORA3 | |
| SCHEMBL16043087 | 0.76 | AR (0.60) | ARMAPTGAARAB9APRKCZ | |
| SCHEMBL7439474 | 0.76 | AR (0.60) | ARMAPTGAARAB9APRKCZ | |
| SCHEMBL30741042 | 0.76 | GCGR (0.55) | ARMAPTGAARAB9APRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957078-A2 | PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING CANCER THROUGH INHIBITION OF AURORA KINASE | Bayer Healthcare, LLC (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007064932-A2 | PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING CANCER THROUGH INHIBITION OF AURORA KINASE | BAYER HEALTHCARE LLC. (US) | 2007-06-07 | — | — | WO | disclosed |