Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 8/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9979815 | 0.91 | AR (0.64) | ARMAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL2659125 | 0.86 | MAPT (0.56) | ARMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7433705 | 0.83 | GABRA1 (0.58) | MAPTMEN1HTTKMT2ARAB9A | |
| SCHEMBL1559220 | 0.83 | CLEC4M (0.49) | MAPTSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL2658810 | 0.83 | TP53 (0.50) | MAPTMEN1KMT2ARAB9ACLEC4M | |
| SCHEMBL7434700 | 0.82 | CLEC4M (0.54) | MAPTGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL2658889 | 0.81 | JAK2 (0.54) | MAPTGAASMN1; SMN2MEN1HTT | |
| SCHEMBL276059 | 0.80 | AR (0.56) | ARMAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL276472 | 0.80 | MAPT (0.58) | ARMAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL276917 | 0.80 | AR (0.59) | ARMAPTGAASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6333336-B1 | GAMMA-AMINOBUTYRIC ACID RECEPTORS AS ANTICONVULSANTS FORMING THE COMPOUND BY AMIDATION | MERCK SHARP & DOHME LTD. (GB) | 2001-12-25 | — | — | US | disclosed |