Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 9/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751807 | 0.97 | MC4R (0.42) | MC4RKMT2AMEN1NTRK1KDM4E | |
| SCHEMBL4019465 | 0.97 | MC4R (0.42) | MC4RKMT2AMEN1NTRK1KDM4E | |
| SCHEMBL4019468 | 0.97 | MC4R (0.42) | MC4RKMT2AMEN1NTRK1KDM4E | |
| SCHEMBL4026815 | 0.93 | MC4R (0.40) | MC4RKMT2AMEN1NTRK1KDM4E | |
| SCHEMBL4749170 | 0.93 | MC4R (0.40) | MC4RKMT2AMEN1NTRK1KDM4E | |
| SCHEMBL4029258 | 0.93 | MC4R (0.40) | MC4RKMT2AMEN1NTRK1KDM4E | |
| SCHEMBL4776650 | 0.92 | MC4R (0.44) | MC4RKMT2AMEN1NTRK1KDM4E | |
| SCHEMBL4776626 | 0.92 | MC4R (0.44) | MC4RKMT2AMEN1NTRK1KDM4E | |
| SCHEMBL5636044 | 0.91 | MC4R (0.39) | MC4RKMT2AMEN1NTRK1KDM4E | |
| SCHEMBL4751989 | 0.90 | MC4R (0.38) | MC4RKMT2AMEN1NTRK1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |