Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 19/20 | 0.67 |
| ▸ | HTR2C | P28335 | 11/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783355 | 0.87 | HTR2A (0.60) | HTR2AHTR2CKCNH2 | |
| SCHEMBL4784011 | 0.86 | HTR2A (0.66) | HTR2AHTR2CKCNH2ALDH1A1 | |
| SCHEMBL4780999 | 0.86 | HTR2A (0.59) | HTR2AHTR2CKCNH2 | |
| SCHEMBL4783828 | 0.85 | HTR2A (0.62) | HTR2AHTR2CKCNH2 | |
| SCHEMBL14205205 | 0.83 | HTR2A (0.60) | HTR2AHTR2CKCNH2ALDH1A1 | |
| SCHEMBL4784178 | 0.81 | HTR2A (0.66) | HTR2AHTR2CKCNH2 | |
| SCHEMBL3143430 | 0.81 | HTR2A (1.00) | HTR2AHTR2CKCNH2 | |
| SCHEMBL4731508 | 0.80 | HTR2A (0.65) | HTR2AHTR2CKCNH2ALDH1A1 | |
| SCHEMBL4732167 | 0.78 | HTR2A (0.65) | HTR2AHTR2CKCNH2ALDH1A1 | |
| SCHEMBL3139406 | 0.77 | HTR2A (1.00) | HTR2AHTR2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |