Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 20/20 | 0.66 |
| ▸ | HTR2C | P28335 | 19/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783828 | 0.87 | HTR2A (0.62) | HTR2AHTR2CKCNH2 | |
| SCHEMBL4784635 | 0.87 | HTR2A (0.67) | HTR2AHTR2CKCNH2 | |
| SCHEMBL4854500 | 0.86 | HTR2A (0.58) | HTR2AHTR2CKCNH2 | |
| SCHEMBL4780094 | 0.81 | HTR2A (0.67) | HTR2AHTR2CKCNH2 | |
| SCHEMBL3134226 | 0.79 | HTR2A (1.00) | HTR2AHTR2CKCNH2 | |
| SCHEMBL29572946 | 0.79 | HTR2A (1.00) | HTR2AHTR2CKCNH2 | |
| SCHEMBL14205791 | 0.77 | HTR2A (0.48) | HTR2AHTR2CKCNH2 | |
| SCHEMBL4782835 | 0.77 | HTR2A (0.64) | HTR2AHTR2C | |
| SCHEMBL14205780 | 0.76 | HTR2A (0.55) | HTR2AHTR2CKCNH2 | |
| SCHEMBL3144161 | 0.75 | HTR2A (0.78) | HTR2AHTR2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |