Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 6/20 | 0.51 |
| ▸ | TACR2 | P21452 | 3/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4667529 | 0.93 | TRPV4 (0.49) | TACR3TACR2OPRM1TMEM97SIGMAR1 | |
| SCHEMBL4665931 | 0.92 | TRPV4 (0.51) | TACR3TACR2OPRM1TMEM97SIGMAR1 | |
| SCHEMBL5001054 | 0.89 | OPRM1 (0.46) | TACR3TACR2OPRM1TMEM97SIGMAR1 | |
| SCHEMBL4668627 | 0.84 | OPRM1 (0.41) | TACR3OPRM1TMEM97SIGMAR1MEN1 | |
| SCHEMBL4668565 | 0.81 | CYP2C9 (0.44) | TACR3OPRM1TMEM97SIGMAR1MEN1 | |
| SCHEMBL4991793 | 0.80 | TACR3 (0.46) | TACR3TACR2OPRM1TRPV4KCNH2 | |
| SCHEMBL27724853 | 0.80 | TACR3 (0.64) | TACR3TACR2OPRM1TRPV4KCNH2 | |
| SCHEMBL4668596 | 0.80 | OPRM1 (0.45) | TACR3OPRM1TMEM97SIGMAR1KCNH2 | |
| SCHEMBL4667560 | 0.80 | MEN1 (0.43) | TACR3OPRM1TMEM97SIGMAR1MEN1 | |
| SCHEMBL4667460 | 0.79 | MEN1 (0.42) | TACR3OPRM1TMEM97SIGMAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940795-A1 | N-OXO-HETEROCYCLE AND N-OXO-ALKYL QUINOLINE-4-CARBOXAMIDES AS NK-3 RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2008-07-09 | — | — | EP | claimed |
| WO-2007035156-A1 | N-OXO-HETEROCYCLE AND N-OXO-ALKYL QUINOLINE-4-CARBOXAMIDES AS NK-3 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | claimed |