Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734472 | 0.92 | KCNH2 (0.41) | ADORA2AADORA2BIRAK4ABL1KAT6A | |
| SCHEMBL12678651 | 0.92 | KCNH2 (0.41) | ADORA2AADORA2BIRAK4ABL1KAT6A | |
| SCHEMBL12678417 | 0.87 | NPBWR1 (0.38) | IRAK4NPBWR1MCHR1PPARDABL1 | |
| SCHEMBL12690573 | 0.84 | NPBWR1 (0.39) | NPBWR1MCHR1PPARDPPARAGPR119 | |
| SCHEMBL12678471 | 0.83 | PPARD (0.38) | NPBWR1MCHR1PPARDPPARAGPR119 | |
| SCHEMBL12680623 | 0.83 | PPARD (0.38) | NPBWR1MCHR1PPARDPPARAGPR119 | |
| SCHEMBL12680480 | 0.83 | GPR119 (0.40) | NPBWR1MCHR1KAT6AKAT8GPR119 | |
| SCHEMBL12678379 | 0.83 | NPBWR1 (0.38) | NPBWR1MCHR1PPARDABL1KAT6A | |
| SCHEMBL12678648 | 0.82 | MEN1 (0.36) | ABL1KAT6AKAT8GRIN2BDYRK1A | |
| SCHEMBL4730577 | 0.82 | MEN1 (0.36) | ABL1KAT6AKAT8GRIN2BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057497-A2 | SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION | CURIS, INC. (US) | 2008-05-15 | — | — | WO | disclosed |