Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780874 | 1.00 | CYP2E1 (0.35) | CYP2E1NR1I2APOBEC3AAPOBEC3GSYK | |
| SCHEMBL4776435 | 0.95 | NR1I2 (0.33) | CYP2E1NR1I2APOBEC3AAPOBEC3GSYK | |
| SCHEMBL4776428 | 0.95 | NR1I2 (0.33) | CYP2E1NR1I2APOBEC3AAPOBEC3GSYK | |
| SCHEMBL4780549 | 0.92 | NR1I2 (0.34) | NR1I2APOBEC3AAPOBEC3GSYK | |
| SCHEMBL4780540 | 0.92 | NR1I2 (0.34) | NR1I2APOBEC3AAPOBEC3GSYK | |
| SCHEMBL14291165 | 0.92 | NR1I2 (0.34) | NR1I2APOBEC3AAPOBEC3GSYK | |
| SCHEMBL4776414 | 0.90 | APOBEC3A (0.32) | APOBEC3AAPOBEC3GSLC6A9 | |
| SCHEMBL4776412 | 0.90 | APOBEC3A (0.32) | APOBEC3AAPOBEC3GSLC6A9 | |
| SCHEMBL14290994 | 0.88 | KDM4E (0.35) | SYKSLC6A9KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL4775789 | 0.87 | CYP2E1 (0.40) | CYP2E1APOBEC3AAPOBEC3GSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008017688-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-14 | — | — | WO | claimed |
| WO-2008017688-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-14 | — | — | WO | disclosed |