Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPR1 | P16066 | 15/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4363108 | 0.89 | NPR1 (0.51) | NPR1IRAK4MERTK | |
| SCHEMBL4356115 | 0.84 | CHEK1 (0.47) | NPR1IRAK4CHEK1CHEK2EGLN1 | |
| SCHEMBL18041181 | 0.74 | CHEK1 (0.42) | NPR1IRAK4CHEK1CHEK2EGLN1 | |
| SCHEMBL4349736 | 0.68 | NPR1 (0.56) | NPR1 | |
| SCHEMBL17269254 | 0.67 | IRAK4 (0.59) | IRAK4 | |
| SCHEMBL4367767 | 0.66 | JAK2 (0.45) | NPR1IRAK4EGLN1 | |
| SCHEMBL4352010 | 0.65 | GABBR2 (0.68) | NPR1IRAK4EGLN1 | |
| SCHEMBL4363691 | 0.65 | GABBR2 (0.50) | NPR1IRAK4EGLN1 | |
| SCHEMBL4367513 | 0.64 | NPR1 (0.55) | NPR1MERTK | |
| SCHEMBL4349987 | 0.64 | NPR1 (0.54) | NPR1MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009078-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | claimed |