Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.58 |
| ▸ | CCR2 | P41597 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4777923 | 0.89 | TRPV1 (0.64) | TRPV1 | |
| SCHEMBL4778931 | 0.84 | TRPV1 (0.55) | TRPV1ROCK2ROCK1CCR2KDM4E | |
| SCHEMBL4776335 | 0.83 | TRPV1 (0.53) | TRPV1ROCK2ROCK1CCR2KDM4E | |
| SCHEMBL4776314 | 0.81 | TRPV1 (0.56) | TRPV1HTT | |
| SCHEMBL4773951 | 0.78 | TRPV1 (0.56) | TRPV1ALDH1A1MAPTHTT | |
| SCHEMBL4779435 | 0.78 | EPHX2 (0.51) | TRPV1ALDH1A1LMNAHPGDHTT | |
| SCHEMBL4019935 | 0.78 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL13841567 | 0.78 | ROCK2 (0.73) | ROCK2ROCK1CCR2 | |
| SCHEMBL4779566 | 0.78 | TRPV1 (0.50) | TRPV1 | |
| SCHEMBL4780244 | 0.78 | TRPV1 (0.50) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008010061-A2 | 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-24 | — | — | WO | claimed |
| WO-2008010061-A2 | 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-24 | — | — | WO | disclosed |