Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.38 |
| ▸ | FEN1 | P39748 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MAP2 | P11137 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4797330 | 0.90 | SCN9A (0.41) | CCR2PTGES2SCN9ARORCCHRNA7 | |
| SCHEMBL4780578 | 0.85 | LMNA (0.42) | PTGES2RORCCHRNA7CA1CA2 | |
| SCHEMBL3218274 | 0.79 | CSF1R (0.43) | CCR2RORCPOLBMAP2 | |
| SCHEMBL305125 | 0.79 | POLB (0.44) | CCR2RORCCDK1CDK4CCND1 | |
| SCHEMBL305288 | 0.78 | CCR2 (0.51) | CCR2PTGES2POLBKDM4EMAPT | |
| SCHEMBL29888324 | 0.78 | CCR2 (0.51) | CCR2PTGES2POLBKDM4EMAPT | |
| SCHEMBL3197579 | 0.75 | CSF1R (0.40) | CCR2RORCCDK1CDK4CCND1 | |
| SCHEMBL15211939 | 0.73 | PTGES2 (0.45) | PTGES2SCN9AALOX5APFEN1CA12 | |
| SCHEMBL29888562 | 0.72 | CCR2 (0.69) | CCR2MAPT | |
| SCHEMBL306221 | 0.72 | CCR2 (0.69) | CCR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008431-A2 | HETEROARYL SULFONAMIDES AND CCR2/CCR9 | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |