Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 8/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.50 |
| ▸ | GSK3B | P49841 | 8/20 | 0.50 |
| ▸ | CLK1 | P49759 | 5/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.50 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.49 |
| ▸ | CDK1 | P06493 | 5/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.49 |
| ▸ | PRKACA | P17612 | 5/20 | 0.49 |
| ▸ | PRKACG | P22612 | 5/20 | 0.49 |
| ▸ | PRKACB | P22694 | 5/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.49 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.49 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.49 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775051 | 0.88 | GSK3B (0.50) | CDK5CDK5R1GSK3BCLK1DYRK1A | |
| SCHEMBL4781310 | 0.83 | PIP4K2A (0.59) | CDK5CDK5R1GSK3BCLK1DYRK1A | |
| SCHEMBL3615777 | 0.82 | GSK3B (0.67) | CDK5CDK5R1GSK3BCLK1DYRK1A | |
| SCHEMBL4914223 | 0.81 | PIK3CD (0.55) | GSK3BPIM1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL4780028 | 0.75 | PRKACA (0.58) | CDK5CDK5R1GSK3BCLK1MAP3K14 | |
| SCHEMBL481304 | 0.74 | PRKACA (0.62) | CDK5CDK5R1GSK3BCLK1DYRK1A | |
| SCHEMBL31456259 | 0.72 | PIK3CD (0.58) | GSK3BPIM1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL6322509 | 0.71 | ASH1L (0.59) | CSNK1DPIK3CDPIK3CBPIK3CGCSNK2B | |
| SCHEMBL4794242 | 0.70 | PIK3CD (0.45) | GSK3BPIM1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL5830444 | 0.70 | PIK3CD (0.58) | CDK5CDK5R1CLK1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280891-A1 | Anti-cancer agents and uses thereof | LOCUS PHARMACEUTICALS, INC. (US) | 2008-11-13 | — | — | US | claimed |
| WO-2008008059-A1 | ANTI-CANCER AGENTS ANS USES THEREOF | LOCUS PHARMACEUTICALS, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| US-20080280891-A1 | Anti-cancer agents and uses thereof | LOCUS PHARMACEUTICALS, INC. (US) | 2008-11-13 | — | — | US | disclosed |
| WO-2008008059-A1 | ANTI-CANCER AGENTS ANS USES THEREOF | LOCUS PHARMACEUTICALS, INC. (US) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280891-A1 | Anti-cancer agents and uses thereof | NR2E3, RB1, CBR3 | CDK5 288/4885CDK5R1 228/4885GSK3B 3241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.