Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 5/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | KMO | O15229 | 1/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.48 |
| ▸ | GSK3B | P49841 | 5/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.48 |
| ▸ | CDK1 | P06493 | 4/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.48 |
| ▸ | PRKACG | P22612 | 4/20 | 0.48 |
| ▸ | PRKACB | P22694 | 4/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.48 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.48 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781250 | 0.88 | PRKACA (0.50) | PRKACAHSP90AA1AURKAADORA2AKMO | |
| SCHEMBL481304 | 0.84 | PRKACA (0.62) | PRKACAHSP90AA1AURKAADORA2AKMO | |
| SCHEMBL474287 | 0.82 | HSP90AA1 (0.66) | PRKACAHSP90AA1AURKAADORA2AKMO | |
| SCHEMBL10917438 | 0.77 | HSP90AA1 (0.58) | PRKACAHSP90AA1AURKAADORA2AKMO | |
| SCHEMBL4781091 | 0.75 | CDK5 (0.50) | PRKACAAURKACDK5CDK5R1GSK3B | |
| SCHEMBL27770164 | 0.74 | KMO (0.55) | PRKACAHSP90AA1AURKAADORA2AKMO | |
| SCHEMBL316210 | 0.74 | HSP90AA1 (1.00) | PRKACAHSP90AA1AURKAADORA2AKMO | |
| SCHEMBL21164006 | 0.74 | HSP90AA1 (0.70) | PRKACAHSP90AA1AURKAADORA2AKMO | |
| SCHEMBL2684649 | 0.74 | HSP90AA1 (0.70) | PRKACAHSP90AA1AURKAADORA2AKMO | |
| SCHEMBL27115833 | 0.73 | KMO (0.59) | PRKACAHSP90AA1AURKAADORA2AKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280891-A1 | Anti-cancer agents and uses thereof | LOCUS PHARMACEUTICALS, INC. (US) | 2008-11-13 | — | — | US | disclosed |
| WO-2008008059-A1 | ANTI-CANCER AGENTS ANS USES THEREOF | LOCUS PHARMACEUTICALS, INC. (US) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280891-A1 | Anti-cancer agents and uses thereof | NR2E3, RB1, CBR3 | PRKACA 3122/4885HSP90AA1 4021/4885AURKA 3710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.