Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1098329 | 0.93 | SIGMAR1 (0.68) | SIGMAR1HPGDALDH1A1HRH3MKNK1 | |
| SCHEMBL161104 | 0.84 | HPGD (0.69) | HPGDALDH1A1L3MBTL3L3MBTL1MAPK1 | |
| SCHEMBL743038 | 0.84 | HPGD (0.63) | HPGDALDH1A1L3MBTL3MAPK1 | |
| SCHEMBL3423662 | 0.83 | SIGMAR1 (0.86) | SIGMAR1HPGDALDH1A1MKNK1MKNK2 | |
| SCHEMBL27978775 | 0.83 | HPGD (0.73) | HPGDALDH1A1L3MBTL3L3MBTL1MAPK1 | |
| SCHEMBL3583338 | 0.83 | HPGD (0.73) | SIGMAR1HPGDALDH1A1MKNK1MKNK2 | |
| SCHEMBL20197 | 0.83 | HPGD (0.73) | HPGDALDH1A1L3MBTL3L3MBTL1MAPK1 | |
| SCHEMBL4796951 | 0.82 | SIGMAR1 (0.58) | SIGMAR1HPGDALDH1A1HRH3MKNK1 | |
| SCHEMBL3063116 | 0.81 | SIGMAR1 (0.60) | SIGMAR1HPGDALDH1A1HRH4 | |
| SCHEMBL14466291 | 0.81 | SIGMAR1 (0.60) | SIGMAR1HPGDALDH1A1HRH3MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008001134-A1 | 1,2,3,8,9,9A-HEXAHYDRO-7H-BENZO(DE)-1,7-NAPHTHYRIDIN-7-ONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2008-01-03 | — | — | WO | disclosed |