Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | MLYCD | O95822 | 1/20 | 0.58 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 3/20 | 0.55 |
| ▸ | CHKA | P35790 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA7 | P43166 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358137 | 0.94 | SIGMAR1 (0.81) | HPGDALDH1A1SIGMAR1L3MBTL3L3MBTL1 | |
| SCHEMBL21650771 | 0.88 | SIGMAR1 (0.58) | HPGDALDH1A1SIGMAR1MAPK1L3MBTL3 | |
| SCHEMBL8260488 | 0.88 | SIGMAR1 (0.72) | HPGDALDH1A1SIGMAR1MAPK1L3MBTL1 | |
| SCHEMBL10721733 | 0.87 | HPGD (0.95) | HPGDALDH1A1MAPK1L3MBTL3L3MBTL1 | |
| SCHEMBL23140495 | 0.86 | SIGMAR1 (0.76) | HPGDALDH1A1SIGMAR1MAPK1L3MBTL3 | |
| SCHEMBL4505138 | 0.86 | SIGMAR1 (0.70) | HPGDALDH1A1SIGMAR1L3MBTL3L3MBTL1 | |
| SCHEMBL14466291 | 0.86 | SIGMAR1 (0.60) | HPGDALDH1A1SIGMAR1L3MBTL3L3MBTL1 | |
| SCHEMBL3063116 | 0.86 | SIGMAR1 (0.60) | HPGDALDH1A1SIGMAR1MEN1KMT2A | |
| SCHEMBL10138693 | 0.86 | GABRD (0.64) | HPGDALDH1A1SIGMAR1MKNK1MKNK2 | |
| SCHEMBL1449107 | 0.86 | SIGMAR1 (0.60) | HPGDALDH1A1SIGMAR1MAPK1L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075953-A1 | SUBSTITUTED PIPERAZINES, (1,4) DIAZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075953-A1 | SUBSTITUTED PIPERAZINES, (1,4) DIAZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS | HRH3, HRH4, HRH2 | HPGD 368/4885ALDH1A1 1903/4885SIGMAR1 487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.