Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | MIF | P14174 | 1/20 | 0.50 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8643077 | 0.83 | MAPT (0.47) | NPC1RAB9APOLBALDH1A1MEN1 | |
| SCHEMBL6731942 | 0.82 | MEN1 (0.60) | NPC1RAB9AMAPK1POLBALDH1A1 | |
| SCHEMBL28489642 | 0.82 | MEN1 (0.60) | NPC1RAB9AMAPK1POLBALDH1A1 | |
| SCHEMBL15227091 | 0.81 | MCL1 (0.61) | NPC1RAB9AMAPK1POLBALDH1A1 | |
| SCHEMBL27800064 | 0.81 | MAPK1 (0.56) | NPC1RAB9AMAPK1POLBALDH1A1 | |
| SCHEMBL2180234 | 0.81 | KMO (0.58) | MAPK1POLBALDH1A1MEN1KMT2A | |
| SCHEMBL17697185 | 0.80 | ASIC3 (0.65) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL18731738 | 0.80 | ASIC3 (0.65) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL29730373 | 0.80 | ASIC3 (0.65) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL25187033 | 0.80 | MAPK1 (0.74) | MAPK1POLBALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |