Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 14/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783817 | 0.80 | PIM1 (0.87) | PIM1ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL4782656 | 0.76 | PIM1 (0.60) | PIM1ALDH1A1L3MBTL1FLT3GSK3B | |
| SCHEMBL24736833 | 0.74 | MKNK1 (0.61) | PIM1MKNK1 | |
| SCHEMBL2763440 | 0.74 | MALT1 (0.67) | PIM1ALDH1A1MKNK1 | |
| SCHEMBL14422647 | 0.73 | PIM1 (1.00) | PIM1ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL5618964 | 0.73 | PIM1 (0.92) | PIM1ALDH1A1FLT3GSK3BJAK2 | |
| SCHEMBL12911405 | 0.72 | LMNA (0.51) | ALDH1A1GLAHPGDNPSR1L3MBTL1 | |
| SCHEMBL11833878 | 0.72 | BRD4 (0.59) | ALDH1A1GLAHPGDNPSR1L3MBTL1 | |
| SCHEMBL14422679 | 0.72 | PIM1 (1.00) | PIM1FLT3GSK3BJAK2CDK2 | |
| SCHEMBL29408652 | 0.72 | PIM1 (1.00) | PIM1FLT3GSK3BJAK2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008069500-A1 | TRIAZOLOPYRIDAZINE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST ACETYL-COA CARBOXYLASE | AMOREPACIFIC CORPORATION (KR) | 2008-06-12 | — | — | WO | claimed |
| WO-2008069500-A1 | TRIAZOLOPYRIDAZINE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST ACETYL-COA CARBOXYLASE | AMOREPACIFIC CORPORATION (KR) | 2008-06-12 | — | — | WO | disclosed |