Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 15/20 | 0.92 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14422681 | 0.96 | PIM1 (1.00) | PIM1FYNFLT3GSK3BCDK2 | |
| SCHEMBL14422676 | 0.82 | PIM1 (1.00) | PIM1FLT3GSK3BCDK2IRAK4 | |
| SCHEMBL4783817 | 0.81 | PIM1 (0.87) | PIM1FLT3GSK3BCDK2IRAK4 | |
| SCHEMBL14422679 | 0.80 | PIM1 (1.00) | PIM1FLT3GSK3BCDK2IRAK4 | |
| SCHEMBL29408652 | 0.80 | PIM1 (1.00) | PIM1FLT3GSK3BCDK2IRAK4 | |
| SCHEMBL14422665 | 0.78 | PIM1 (1.00) | PIM1FLT3GSK3BCDK2IRAK4 | |
| SCHEMBL14422677 | 0.78 | PIM1 (1.00) | PIM1FLT3GSK3BCDK2IRAK4 | |
| SCHEMBL23733342 | 0.78 | PIM1 (0.71) | PIM1FLT3GSK3BCDK2IRAK4 | |
| SCHEMBL5634432 | 0.77 | PIM1 (0.70) | PIM1CDK2IRAK4MAPTHSD17B10 | |
| SCHEMBL14422647 | 0.77 | PIM1 (1.00) | PIM1FYNFLT3GSK3BCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7173033-B2 | Nitrogen-containing heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2007-02-06 | — | — | US | disclosed |
| US-20060173009-A1 | Agent inducing increase in bone mass | ASTELLAS PHARMA INC. (JP) | 2006-08-03 | — | — | US | disclosed |
| EP-1640010-A1 | AGENT INDUCING INCREASE IN BONE MASS | Astellas Pharma Inc. (JP) | 2006-03-29 | — | — | EP | disclosed |
| US-20050261297-A1 | Nitrogen-containing heterocyclic compound | YAMANOUCHI PHARMACEUTICAL CO., LTD | 2005-11-24 | — | — | US | disclosed |
| US-20050096322-A1 | Nitrogen-containing heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2005-05-05 | — | — | US | disclosed |
| EP-1481977-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2004-12-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096322-A1 | Nitrogen-containing heterocyclic compound | BMP2, BMP1, BMP4 | PIM1 4018/4885FYN 1140/4885FLT3 629/4885 |
| US-20050261297-A1 | Nitrogen-containing heterocyclic compound | BMP2, BMP1, BMP4 | PIM1 4018/4885FYN 1140/4885FLT3 629/4885 |
| US-20060173009-A1 | Agent inducing increase in bone mass | SOST, CALCB, BMP4 | PIM1 1851/4885FYN 3675/4885FLT3 3056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.