Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | APOB | P04114 | 1/20 | 0.37 |
| ▸ | MTTP | P55157 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781658 | 1.00 | KDM4E (0.43) | KDM4EPOLBTDP1L3MBTL1GAA | |
| SCHEMBL4782858 | 0.84 | KDM4E (0.44) | KDM4EPOLBTDP1L3MBTL1GAA | |
| SCHEMBL4782869 | 0.84 | KDM4E (0.44) | KDM4EPOLBTDP1L3MBTL1GAA | |
| SCHEMBL4784130 | 0.83 | NR1H2 (0.43) | KDM4EPOLBTDP1L3MBTL1GAA | |
| SCHEMBL4784118 | 0.83 | NR1H2 (0.43) | KDM4EPOLBTDP1L3MBTL1GAA | |
| SCHEMBL4782285 | 0.82 | NR1H2 (0.51) | KDM4EPOLBTDP1L3MBTL1GAA | |
| SCHEMBL4782289 | 0.82 | NR1H2 (0.51) | KDM4EPOLBTDP1L3MBTL1GAA | |
| SCHEMBL4784495 | 0.80 | CA1 (0.44) | L3MBTL1NR1H2MEN1KMT2A | |
| SCHEMBL4782205 | 0.80 | CA1 (0.50) | KDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL4797405 | 0.78 | MAPT (0.43) | NR1H2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |