Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486905 | 0.91 | PTGER4 (0.35) | PTGER4SLC6A3KDM4CMEN1MAPT | |
| SCHEMBL7446726 | 0.89 | PTGER4 (0.46) | PTGER4SLC6A3KDM4CCCNA2CDK2 | |
| SCHEMBL7400415 | 0.88 | PTGER4 (0.33) | PTGER4SLC6A3KDM4CCYP1A2CYP3A4 | |
| SCHEMBL29167883 | 0.80 | SLC6A3 (0.44) | PTGER4SLC6A3KDM4CMEN1MAPT | |
| SCHEMBL8172478 | 0.79 | KDM4E (0.40) | PTGER4SLC6A3MEN1MAPTKMT2A | |
| SCHEMBL7401906 | 0.78 | SLC6A3 (0.36) | PTGER4SLC6A3MEN1KMT2ACCNA2 | |
| SCHEMBL8168868 | 0.77 | KDM4E (0.40) | SLC6A3MAPTLMNASMN1; SMN2NPSR1 | |
| SCHEMBL7445316 | 0.77 | SLC6A3 (0.40) | PTGER4SLC6A3MEN1KMT2ALMNA | |
| SCHEMBL8172480 | 0.74 | HTR7 (0.40) | PTGER4MAPTLMNA | |
| SCHEMBL8168899 | 0.72 | PTGER4 (0.38) | PTGER4MEN1MAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023157-A1 | NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS USEFUL AS M3-RECEPTOR MODULATORS | ARGENTA DISCOVERY LIMITED (GB) | 2008-02-28 | — | — | WO | disclosed |
| US-6060472-A | Thiadiazole compounds useful as inhibitors of H+ /K+ atpase | APOTEX INC. (CA) | 2000-05-09 | — | — | US | disclosed |
| WO-1999051584-A1 | THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF H+/K+ ATPASE | APOTEX INC. (CA) | 1999-10-14 | — | — | WO | disclosed |
| US-5405853-A | Potent muscarinic agonists having good central nervous system penetrability | MERCK SHARPE & DOHME LTD. (GB) | 1995-04-11 | — | — | US | disclosed |
| EP-0307142-B1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-09-14 | — | — | EP | disclosed |
| EP-0307142-A1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |