Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 13/20 | 0.62 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | WNT3 | P56703 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | GALK1 | P51570 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731426 | 0.94 | SFRP1 (0.60) | SFRP1HTR1AHTR7WNT3GALK1 | |
| SCHEMBL4733633 | 0.92 | SFRP1 (0.64) | SFRP1GALK1EPHX2KDM4E | |
| SCHEMBL4731868 | 0.90 | SFRP1 (0.64) | SFRP1WNT3GALK1EPHX2 | |
| SCHEMBL4734128 | 0.88 | SFRP1 (0.66) | SFRP1WNT3GALK1EPHX2 | |
| SCHEMBL4733626 | 0.88 | SFRP1 (0.64) | SFRP1WNT3GALK1EPHX2 | |
| SCHEMBL4734316 | 0.88 | SFRP1 (0.67) | SFRP1WNT3GALK1EPHX2 | |
| SCHEMBL4731282 | 0.88 | SFRP1 (0.67) | SFRP1GALK1EPHX2 | |
| SCHEMBL4731627 | 0.87 | SFRP1 (0.61) | SFRP1WNT3GALK1EPHX2KDM4E | |
| SCHEMBL4734239 | 0.87 | SFRP1 (0.64) | SFRP1GALK1EPHX2 | |
| SCHEMBL4782887 | 0.86 | SFRP1 (0.72) | SFRP1GALK1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |