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SCHEMBL4782887

SCHEMBL4782887

O=C(O)c1cccc(S(=O)(=O)N2CCC(NS(=O)(=O)c3ccc(-c4ccc(-c5ccccc5)cc4)cc3C(F)(F)F)CC2)c1

nearest known ligand 0.72

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ SFRP1 Q8N474 13/20 0.72
▸ GALK1 P51570 1/20 0.49
▸ EPHX2 P34913 1/20 0.48
▸ MEN1 O00255 2/20 0.48
▸ KMT2A Q03164 2/20 0.48
▸ MAPT P10636 2/20 0.47
▸ IL1RN P18510 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4737386 1.00 SFRP1 (0.72) SFRP1GALK1EPHX2MEN1KMT2A
SCHEMBL4731797 0.94 SFRP1 (0.67) SFRP1GALK1EPHX2MAPTIL1RN
SCHEMBL4731856 0.93 SFRP1 (0.68) SFRP1GALK1EPHX2MEN1KMT2A
SCHEMBL4734796 0.93 SFRP1 (0.66) SFRP1GALK1EPHX2MEN1KMT2A
SCHEMBL4784004 0.93 SFRP1 (0.66) SFRP1GALK1EPHX2MEN1KMT2A
SCHEMBL4734355 0.92 SFRP1 (0.75) SFRP1GALK1EPHX2MEN1KMT2A
SCHEMBL4732050 0.92 SFRP1 (0.64) SFRP1GALK1EPHX2MEN1KMT2A
SCHEMBL4736599 0.92 SFRP1 (0.64) SFRP1GALK1EPHX2MEN1KMT2A
SCHEMBL4734031 0.92 SFRP1 (0.64) SFRP1GALK1EPHX2MEN1KMT2A
SCHEMBL4735866 0.91 SFRP1 (0.66) SFRP1GALK1EPHX2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 — — WO disclosed