Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.44 |
| ▸ | GHSR | Q92847 | 1/20 | 0.44 |
| ▸ | SLC20A2 | Q08357 | 1/20 | 0.44 |
| ▸ | SLC20A1 | Q8WUM9 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3083591 | 0.87 | SLC20A2 (0.54) | AXLMEN1KMT2AGAALMNA | |
| SCHEMBL3101140 | 0.87 | SLC20A2 (0.52) | AXLMEN1KMT2AGAALMNA | |
| SCHEMBL4777395 | 0.83 | AXL (0.54) | AXLMEN1KMT2AGAALMNA | |
| SCHEMBL30304653 | 0.82 | MEN1 (0.57) | MEN1KMT2AGAALMNANPSR1 | |
| SCHEMBL4779095 | 0.82 | MEN1 (0.57) | MEN1KMT2AGAALMNANPSR1 | |
| SCHEMBL4725832 | 0.81 | LMNA (0.47) | MEN1KMT2AGAALMNANPSR1 | |
| SCHEMBL4780290 | 0.81 | MEN1 (0.50) | MEN1KMT2AGAALMNANPSR1 | |
| SCHEMBL4781931 | 0.81 | GAA (0.50) | MEN1KMT2AGAALMNANPSR1 | |
| SCHEMBL4781581 | 0.79 | AXL (0.49) | AXLMEN1KMT2AGAAALOX15 | |
| SCHEMBL4780564 | 0.78 | AXL (0.47) | AXLMEN1KMT2AGAAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |