SCHEMBL4781883

SCHEMBL4781883

O=C(O)C(=O)N1CCC(NS(=O)(=O)c2cn(S(=O)(=O)c3ccccc3)c3cccc(C(F)(F)F)c23)CC1

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SFRP1 Q8N474 20/20 0.52
WNT3 P56703 4/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4783460 0.94 SFRP1 (0.50) SFRP1WNT3
SCHEMBL4783752 0.92 SFRP1 (0.47) SFRP1WNT3
SCHEMBL4879740 0.90 SFRP1 (0.47) SFRP1WNT3
SCHEMBL4785194 0.90 SFRP1 (0.65) SFRP1WNT3
SCHEMBL4784964 0.89 SFRP1 (0.58) SFRP1WNT3
SCHEMBL4781750 0.89 SFRP1 (0.57) SFRP1WNT3
SCHEMBL4785274 0.87 SFRP1 (0.45) SFRP1WNT3
SCHEMBL4785281 0.87 SFRP1 (0.45) SFRP1WNT3
SCHEMBL4783391 0.87 SFRP1 (0.46) SFRP1WNT3
SCHEMBL4783395 0.87 SFRP1 (0.46) SFRP1WNT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008060998-A1 INDOLE SULFONAMIDES AS SFRP-1 MODULATORS WYETH (US) 2008-05-22 WO claimed
WO-2008060998-A1 INDOLE SULFONAMIDES AS SFRP-1 MODULATORS WYETH (US) 2008-05-22 WO disclosed
WO-2008060998-A1 INDOLE SULFONAMIDES AS SFRP-1 MODULATORS WYETH (US) 2008-05-22 WO disclosed